Measurement of depth-resolved thermal deformation distribution using phase-contrast spectral optical coherence tomography

Phase-resolved spectral-domain magnetomotive optical coherence tomography

We advance the magnetomotive-optical coherence tomography (MM-OCT) technique for detecting displacements of magnetic nanoparticles embedded in tissue-like phantoms by using apmplitude and phase-resolved methods with spectral-domain optical coherence tomography (SD-OCT). The magnetomotion is triggered by the external, noninvasive application of a magnetic field. We show that both amplitude and p...

Depth resolved detection of lipid using spectroscopic optical coherence tomography.

Optical frequency domain imaging (OFDI) can identify key components related to plaque vulnerability but can suffer from artifacts that could prevent accurate identification of lipid rich regions. In this paper, we present a model of depth resolved spectral analysis of OFDI data for improved detection of lipid. A quadratic Discriminant analysis model was developed based on phantom compositions k...

3 Phase - Resolved Doppler Optical Coherence Tomography

Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography.

We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understan...

Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography.

Phase variance-based motion contrast is demonstrated using two phase analysis methods in a spectral domain optical coherence tomography system. Mobility contrast is demonstrated for an intensity matched Intralipid solution placed without flow within agarose wells. Vasculature oriented transversely to the imaging direction has been imaged for 3-4 dpf in vivo zebrafish using the phase variance co...